Within the campaign settings => targeting, you can negate GEO, provider, speed and IP targetings:
All targetings depend on each other (negated and normal), meaning e.g.:
- Geo targeting normal - germany is selected
- Provider targeting normal - Telekom is selected
- Speed targeting negated - 'DSL/Cabel is selected
- IP targeting negated - IP 220.127.116.11 is selected
=> You would now be able to play out your campaign on all German IP's and Telekom with the exception of DSL/Cable connections and IP 18.104.22.168.
Each creative can overwrite its campaign targetings, therefore you have to check this creative checkbox: